A study of nearly 58,000 people finds high-dose
statins -cholesterol-lowering drugs - appeared to prevent dementia in older
people, U.S. researchers say.
Dr. Tin-Tse Lin of Taiwan and colleagues examined
whether statin use was associated with new diagnoses of dementia from a random
sample of 1 million patients covered by Taiwan's National Health Insurance.
From this they identified 57,669 patients age 65 and
older, who had no history of dementia in 1997 and 1998. The analysis included
pre-senile and senile dementia but excluded vascular dementia.
"Statins are widely used in the older population
to reduce the risk of cardiovascular disease. But recent reports of
statin-associated cognitive impairment have led the U.S. Food and Drug
Administration to list statin-induced cognitive changes,
especially for the older population, in its safety communications," Lin
said in a statement.
The study found 5,516 new diagnoses of dementia during
approximately 4.5 years of follow-up. The remaining 52,153 patients age 65 and
older formed the control group.
Subjects were divided into tertiles -- thirds --
according to their mean daily equivalent dosage and total equivalent dosage.
The adjusted risks for dementia were significantly
inversely associated with increased total or daily equivalent statin dosage.
For example, "patients who received the highest
total equivalent doses of statins had a three-fold decrease in the risk of
developing dementia. Similar results were found with the daily equivalent
statin dosage," Lin said. "It was the potency of the statins rather
than their solubility which was a major determinant in reducing dementia. High
potency statins such as atorvastatin and rosuvastatin showed a significant
inverse association with developing dementia in a dose-response manner. Higher
doses of high potency statins gave the strongest protective effects against
dementia."
The findings were presented at the European Society of
Cardiology Congress in Amsterdam.
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